SKELETAL MUSCLE RELAXANTS

Skeletal muscle relaxants are the drugs that act peripherally at neuromuscular junction . It relaxes the skeletal muscle by reducing the muscle tone. During surgery to reduce muscle movement these are given in conjugation with general anesthetics drugs.

NEURO MUSCULAR BLOCKING AGENTS

These are the chemical compounds which block the nicotinic receptor present in neuro muscular junction (Nm). Acetylcholine does not bind the nicotinic receptors & muscle relaxation occour.

TRICK TO REMEMBER NON DEPOLARIZING BLOCKERS

Non depolarizing blockers bind with the Nm receptors, prevent the binding of acytylcholine. These are of three types i.e. 1.Long acting, 2. Intermediate acting, 3. Short acting

Trick for long acting

TRICK Didi Pipecuronium ko Pan Do.

TRICKNAME OF THE DRUG
DDidiD – TUBOCURARINE
P PipecuroniumPIPECURONIUM
PPanPANCURONIUM
D DoDOXACURIUM

Trick for intermediate acting

TRICK VACcine devloped by Rapa in Russia .

TRICKNAME OF THE DRUG
V VACcineVECURONIUM
A – VACcineATRACURIUM
C – VACcineCISATRACURIUM
RRapaRAPACURONIUM
RRussiaROCURONIUM

Short acting

MIVACURIUM

DEPOLARIZING BLOCKERS

Depolarizing blockers bind with the Nm receptors & act as same as acetylcholine but it is not degraded by esterases . So excessive depolarization occurs which results repolarization .

SUCCINYL CHOLINE

DIRECTLY ACTING AGENTS

These are the agents which directly act on the calcium channel present in sarcoplasmic reticulum of skeletal muscles and prevent the influx of calcium ions.

DANTROLENE sod., QUININE

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